Predicted Hazard of Gene Therapie a Reality

Predicted Hazard of Gene Therapy A Reality

I-SIS was almost a lone voice warning of cancer from foreign genes inserting into the genome in ‘gene therapy’ and other exposures to transgenic DNA. Regrettably, this has now become reality.
Dr. Mae-Wan Ho calls for a comprehensive review of gene therapy and other transgenic technologies, for they carry similar risks.

The French team that made news in 2000 treating children with severe combined immune deficiency (SCID) had to call a halt to the gene therapy trial. One of the ten children treated has developed what looks like leukaemia.
(bron: Source: Science, News of the Week, 4 October 2002)

Metabolism of  14C-Glufosinate and 14C-N-Acetyl-Glufosinate in lactating goats en laying hens.


Glufosinate ammonium (ammonium homoalanin-4-yl(methyl)phosphinate) and N-acetyl-glufosinate (the major metabolite in glufosinate resistant crops) were administered orally to lactating goats and laying hens. Goats were dosed with either glufosinate ammonium or N-acetyl-glufosinate for four and three days, respectively at approximately 92 ppm in the diet representing 60-75 times the maximum residue level expected in ruminant feed. Hens were dosed for fourteen days with either glufosinate ammonium or N-acetyl-glufosinate at approximately 26 ppm, representing 10 times the maximum residue level in poultry feed. Total radioactive residue levels were determined for tissues, eggs and milk (as appropriate). Glufosinate and N-acetyl-glufosinate were rapidly eliminated from ruminants and poultry, with a similar metabolic profile being found for each compound in both species. Glufosinate was metabolized to MP-propionic acid (3-methylphosphinicopropionic acid) with a minor amount of N-acetyl-glufosinate and MP-acetic acid. (2-methylphosphinico-acetic acid) N-acetyl-glufosinate was readily de-acetylated to glufosinate with further metabolism to MP-propionic acid and MP-acetic acid.

== Auteur(s) ==
* M N Huang. J.K. Rupprecht*, K.A. Stumpf*, and S.M. Smith, AgrEvo USA, Co., 703 NOR-AM Road, Pikeville, NC 27863, *Hoechst Schering AgrEvo GmbH, Frankfurt, Germany (1995)

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