CRISPR–Cas9 bij therapeutisch gebruik mogelijk kankerverwekkend.

Brief Communication | Published: CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Quote of Abstract

“Here, we report that genome editing by CRISPR–Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway…… ” More

From: Nature Medicine (2018) | Download Citation 

and

Genome-editing tool could increase cancer risk

Published 2018-06-11 17:01. Updated 2018-06-12 09:54

From: Karolinska Institutet.

Quote:

“Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer, according to a new study from Karolinska Institutet and the University of Helsinki published in Nature Medicine. Researchers say that more studies are required in order to guarantee the safety of these ‘molecular scissors’ ……..More

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