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Cotton GHB614

Assessment of genetically modified cotton GHB614 for renewal authorisation under Regulation (EC) No 1829/2003 (application EFSA-GMO-RX-018)

EFSA opinion: 07 July 2021 More More 2

Deadline: 9 August 2021

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Genetically modified (GM) cotton GHB614 (Unique Identifier BCS-GHØØ2-5) developed to provide tolerance to glyphosate-based herbicides.

Cotton GHB614 is derived from the cotton variety Coker 312 that was transformed by Agrobacterium-mediated gene transfer technology. Cotton GHB614 expresses a modified epsps (2mepsps) maize gene leading to the production of a modified 5-enolpyruvyl-shikimate-3-phosphate synthase (2mEPSPS) enzyme that confers tolerance to glyphosate-based herbicides.

Gene: 2mepsps

Gene Source: Zea mays
Product: 5-enolpyruvyl shikimate-3-phosphate synthase enzyme (double mutant version)
Function: decreases binding affinity for glyphosate, thereby increasing tolerance to glyphosate herbicide. Source


As a legal dossier compiled by Professor Ludwig Kraemer shows, EU regulations require the monitoring of effects on health at the stage of consumption. This is especially relevant in this case, because of the elevated level of gossypol that has been found, and because a specific pattern of residues from spraying with herbicides can be expected in the plants. Directive 2001/18 and Regulation 1829/2003 both require that potential adverse effects on human health from genetically modified plants are monitored during the use and consumption stage. Therefore, the EFSA opinion that monitoring the effects on health is unnecessary contradicts current EU regulations.


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